| Title |
The role of T and NonT/nonB (N) lymphocytes in the immune response to Mycobacteria |
| Author(s) |
Davis WC1,
Chiodini RJ2,
Monaghan M3.
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| Institution(s) |
1Dept. Vet. Micro, and Pathology, Wash. State Univ., Pullman, WA 99164-7040 USA, 2Dept. Med., Brown Univ. and RI Hospital, RI 02903 USA, 3Dept. Large Animal Clinical Studies, Univ. College Dublin, Ballsbridge, Dublin Ireland.
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| Source |
Third International Colloquium on Paratuberculosis
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| Section |
5:
Immunology and Pathogenesis
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| Abstract |
Studies undertaken to detail the composition of the bovine immune system have shown it is composed of three partially overlapping populations of lymphocytes: B cells defined by the expression of sIgM and lineage specific membrane molecules, T cells defined by the expression of the alpha-beta TCR, BoCD2, -CD3, -CD5, -CD6 in association with -CD4 or -CD8, and nonT/nonB (N) cells defined by the expression of an unique molecule N12, -CD3, and -CD5. Analysis of the N12+ population has shown it is composed of two subpopulations: 1) a large population composed of multiple subsets that express the gamma delta TCR, workshop cluster 1 (SC1), and lineage specific molecules, and 2) a small population composed of subsets that express -CD2 and -CD6 alone or in association with -CD8 or -CD8 and the gamma delta TCR. Preliminary studies suggest gamma delta + N lymphocytes may play a significant role in the regulation and expression of T cell responses to M. bovis and M. paratuberculosis in ruminants.
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