Bovine paratuberculosis FGDS22 - Control program in Cotes de'Amor, France uses fecal culture in high clinical incidence herds to cull infected cattle before clinical onset. Many thousands of cattle have been cultured one or more times since 1982. The first two tests and cull operations in infected herds at 1 year intervals have the best cost/benefit ratio to lower clinical rate and occurrence of persistent excretors which are the source of infections for calves. The cultures performed in the following years are less useful. Statistical results are presented according to the age of cattle, for cattle born before or after the beginning of hygienic control measures in the herds and for cattle vaccinated or not. Vaccination appears to be the key factor of the control program.