M.avium subspecies paratuberculosis causes bovine paratuberculosis and suspected to be possible participation to human Crohn's disease. Immunological diagnosis is ineffective in anergic state in the long incubation period (IP), for 3 to over 6 years, however, bacterial isolation from faecal sample is a reliable diagnostic method in the anergic state. So many bacteria/day are shed into faeces in the clinical and subclinical stages. However, no evidence of the shedding mechanism of the bacteria in the granulomas to intestinal lumen, through the mucosal epithelial barrier. We report here that novel passive shedding mechanism by using host macrophages that treat apoptotic epithelial cells in constant epithelial renewal. These results and fact that they enter through M-cells, strongly emphasise the successful nature of the bacterial that invade and escape passively by using host physiological function without any damage.