Title A comparison of the virulence of strains of Mycobacterium avium subsp. paratuberculosis isolated from different host species.
Author(s) Stevenson K1*, Schock A1, Sales J2, Sharp JM1.
Institution(s) 1 Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK. 2 Biomathematics and Statistics Scotland, King's Buildings, Edinburgh, Scotland, UK.
Source Seventh International Colloquium on Paratuberculosis
Section 2: Pathogenesis
Abstract
A mouse model for paratuberculosis has been optimised and used to compare the virulence of strains of M. a. paratuberculosis isolated from different host species. C57/BL6 mice were inoculated with different strains of M. a. paratuberculosis previously characterised by pulsed-field gel electrophoresis and restriction fragment length polymorphism analysis (cervine, bovine, pigmented ovine, non-pigmented ovine and human). Control mice were inoculated with heat-killed cervine strain, PBS or IS901+ M.avium. A necropsy was performed after 8 weeks. Body, spleen and liver weights were recorded and the livers were examined histopathologically for the presence of granulomas and cultured to determine the presence of viable organisms. Data will be presented to show the different virulence characteristics observed between the various strains.
Source: http://www.paratuberculosis.org/pubs/proc7/abst2_o13.htm
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